Pivotal Advance: Invariant NKT cells reduce accumulation of inflammatory monocytes in the lungs and decrease immune‐pathology during severe influenza A virus infection

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: iNKT;    chemokines;    respiratory viruses;    innate immune response;    lung injury;   

DOI  :  10.1189/jlb.0411184

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

LittleisknownofhowastrongimmuneresponseinthelungsisregulatedtominimizetissueinjuryduringsevereinfluenzaAvirus(IAV)infection.Here,usingamodeloflethal,high‐pathogenicityIAVinfection,wefirstshowthatLy6ChiLy6G–inflammatorymonocytes,andnotneutrophils,arethemaininfiltrateinlungsofWTmice.MicedevoidofiNKTcells(Jα18−/−mice)haveincreasedlevelsofinflammatorymonocytes,whichcorrelatedwithincreasedlunginjuryandmortality(butnotviralload).ActivationofiNKTcellscorrelatedwithreductionofMCP‐1levelsandimprovedoutcome.iNKTcellswereabletoselectivelylyseinfected,MCP‐1‐producingmonocytesinvitro,inaCD1d‐dependentprocess.OurstudyprovidesadetailedprofileandkineticsofinnateimmunecellsinthelungsduringsevereIAVinfection,highlightinginflammatorymonocytesasthemajorinfiltrateandidentifyingaroleforiNKTcellsincontrolofthesecellsandlungimmune‐pathology...

【 授权许可】

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