Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
The dual roles of inflammatory cytokines and chemokines in the regulation of autoimmune diseases and their clinical implications | |
关键词: TGF‐; β; IL‐; 10; IL‐; 2; IFN‐; γ; CCL2; CXCL12; | |
DOI : 10.1189/jlb.0612293 | |
学科分类:生理学 | |
来源: Federation of American Societies for Experimental Biology | |
【 摘 要 】
Cytokinesandchemokinesaresecreted,smallcell‐signalingproteinmolecules,whosereceptorsareexpressedonimmunecells.Thesefactorsplayacriticalroleinimmunecelldifferentiation,migration,andpolarizationintofunctionalsubtypesandindirectingtheirbiologicalfunctions.Muchattentionhasbeendevotedtoexploringtheroleofkeyinflammatorycytokinesandpromigratorychemokinesinautoimmune,autoinflammatory,andallergicdiseases,leadingtodevelopmentoftherapeuticstrategiesthatarebasedontheirtargetedneutralization.Recentstudies,includingthosecomingfromourgroups,showthatseveralmajorproinflammatorycytokinesandchemokines,includingIFN‐γ,IL‐2,CCL2,andCXCL12,mayalsofunctionasanti‐inflammatorymediatorsandtherefore,mayhavepotentialasanti‐inflammatorydrugs.Likewise,majoranti‐inflammatorymediators,suchasTGF‐β,mayundercertainconditions,incombinationwithothercytokines,exhibitproinflammatoryfunctionanddirectthepolarizationofthehighlyinflammatoryCD4+Th17cells.Weshowherethatthebiologicalfunctionofpro‐andanti‐inflammatorycytokinesisdependentonthreekeyparameters:thelocalconcentrationofagivencytokine,thestageofdiseaseinwhichitisadministered,anditscombinationwithothercytokines.Thetherapeuticimplicationsofthesefindingsarediscussed,includingtwoveryrecentstudiessummarizingclinicaltrials,inwhichlow‐doseadministrationofIL‐2wasusedtosuccessfullysuppressHCVandGVHD...
【 授权许可】
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