| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| Role of immune‐regulatory cells in skin pathology | |
| 关键词: myeloid‐; derived suppressor cell; cancer; psoriasis; dermatitis; Treg; burns; transplant; | |
| DOI : 10.1189/jlb.0410229 | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
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【 摘 要 】
Theskinharborsacomplexanduniqueimmunesystemthatprotectsagainstvariouspathologies,suchasinfectionandcancer.Althoughmanyofthemechanismsofimmuneactivationintheskinhavebeeninvestigated,itislikewiseimportanttouncovertheimmune‐regulatorycomponentsthatlimiteffectiveimmunityorpreventautoimmunity.Severalcellpopulationsareinvolvedinthisimmune‐regulatoryfunction,includingCD4+TcellsthatcoexpressthetranscriptionfactorFoxp3,knownasTregs,andcellswithimmune‐regulatoryfunctionknownasmyeloid‐derivedsuppressorcells(MDSCs).Thisreviewfocusesontherolethatimmune‐regulatorycells,suchasMDSCsandTregs,playincutaneouspathology,suchasmalignancy,psoriasis,dermatitis,burnwounds,andtransplantation.Althoughtheirdepletionmayservetoaugmentimmunity,expansionofthesecellsmaybeusedtosuppressexcessiveimmunereactions.Thesecellsareattractive,therapeutictargetsforvariousconditionsandthus,deservefurtherexploration...
【 授权许可】
CC BY
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201904044642534ZK.pdf | 508KB |  download |
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