期刊论文详细信息
| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| The mannose receptor | |
| 关键词: Lectin receptor; antigen presentation; macrophages; dendritic cells; mouse; human; endocytosis; glycosylation; | |
| DOI : 10.1189/jlb.0512231 | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
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【 摘 要 】
TheMRisahighlyeffectiveendocyticreceptorwithabroadbindingspecificityencompassingligandsofmicrobialandendogenousoriginandapoorlycharacterizedabilitytomodulatecellularactivation.Thisreviewprovidesanupdateofthelatestdevelopmentsinthefield.ItdiscusseshowMRbiologymightbeaffectedbyglycosylationandproteolyticprocessing,MRinvolvementinantigendelivery,andthepotentialcontributionofMRtoTcelldifferentiationandcellularactivation.Furtherunderstandingoftheseareaswill,nodoubt,informthedesignofnovel,therapeutictoolsforimprovedvaccination,controlofinflammation,andtumorchemotherapy,whichwillbenefitfromexploitingMR‐efficientinternalizationpropertiesanduniquepatternofexpression...
【 授权许可】
CC BY
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201904044419793ZK.pdf | 858KB |  download |
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