Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
Purinergic signaling during macrophage differentiation results in M2 alternative activated macrophages | |
关键词: adenosine; Ym1; extracellular ATP; purinergic receptors; adenosine receptors; | |
DOI : 10.1189/jlb.1A0514-267RR | |
学科分类:生理学 | |
来源: Federation of American Societies for Experimental Biology | |
【 摘 要 】
Macrophagesrepresentahighlyheterogeniccellpopulationoftheinnateimmunesystem,withimportantrolesintheinitiationandresolutionoftheinflammatoryresponse.PurinergicsignalingregulatesbothM1andM2macrophagefunctionatdifferentlevelsbycontrollingthesecretionofcytokines,phagocytosis,andtheproductionofreactiveoxygenspecies.WefoundthatextracellularnucleotidesarrestmacrophagedifferentiationfrombonemarrowprecursorsviaadenosineandP2receptors.ThisresultsinamaturemacrophagewithincreasedexpressionofM2,butnotM1,genes.SimilartoadenosineandATP,macrophagegrowtharrestedwithLPStreatmentresultedinanincreaseoftheM2‐relatedmarkerYm1.RecombinantYm1wasabletoaffectmacrophageproliferationandcould,potentially,beinvolvedinthearrestofmacrophagegrowthduringhematopoiesis...
【 授权许可】
CC BY
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