| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| Purinergic signaling during macrophage differentiation results in M2 alternative activated macrophages | |
| 关键词: adenosine; Ym1; extracellular ATP; purinergic receptors; adenosine receptors; | |
| DOI : 10.1189/jlb.1A0514-267RR | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
 PDF
|
|
【 摘 要 】
Macrophagesrepresentahighlyheterogeniccellpopulationoftheinnateimmunesystem,withimportantrolesintheinitiationandresolutionoftheinflammatoryresponse.PurinergicsignalingregulatesbothM1andM2macrophagefunctionatdifferentlevelsbycontrollingthesecretionofcytokines,phagocytosis,andtheproductionofreactiveoxygenspecies.WefoundthatextracellularnucleotidesarrestmacrophagedifferentiationfrombonemarrowprecursorsviaadenosineandP2receptors.ThisresultsinamaturemacrophagewithincreasedexpressionofM2,butnotM1,genes.SimilartoadenosineandATP,macrophagegrowtharrestedwithLPStreatmentresultedinanincreaseoftheM2‐relatedmarkerYm1.RecombinantYm1wasabletoaffectmacrophageproliferationandcould,potentially,beinvolvedinthearrestofmacrophagegrowthduringhematopoiesis...
【 授权许可】
CC BY
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201904044229149ZK.pdf | 751KB |  download |
878987797
028-85220240
