Leishmanial lipid suppresses the bacterial endotoxin‐induced inflammatory response with attenuation of tissue injury in sepsis

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: Leishmania ;    macrophage;    lipopolysaccharide;    inflammation;    septic damage;   

DOI  :  10.1189/jlb.3A1113-582R

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Theuseoflive,attenuated,orgeneticallymodifiedmicrobesortheircellularcomponent(s)ormetaboliteshasbeguntoemergeasapotentialnewapproachinmedicinalresearchtodeliverbiologicallyactiveentities.Thus,advancingourknowledgeofsuchmicrobe‐mediatedtherapymaysuggestnewavenuesfortherapeuticinterventioninmanydiseases.WehadearlierreportedthatthetotallipidofattenuatedLeishmaniadonovanisuppressedtheinflammatoryresponsesinrheumatoidarthritispatients.OurpresentstudyrevealsthatthepLLD,isolatedfrompathogenicL.donovani,decreasestheinflammatorylevelofbacterialendotoxininstimulatedmousemacrophages,asalsointheinvivomurinesystem.Itexertstheactivitybyreducingthelevelofdifferentmediators,suchascytokine‐chemokine(s).ItalsosuppressestheexpressionoftheubiquitoustranscriptionfactorNF‐κBp65instimulatedmacrophagecells,improvestheendotoxin‐associatedliverdamage,reducesthevascularpermeabilityfactors,suchasVEGF,andsuppressestheexpressionofcelladhesionmolecules,includingICAM‐1,VCAM‐1,PECAM‐1,P‐selectin,andE‐selectin,inliverofsepticmice.ThesefindingsindicatethatpLLDmayprovetobeapotentialanti‐inflammatoryagentandprotectfromendotoxin‐inducedsepsisinhepaticimpairment...

【 授权许可】

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