ASSOCIATION OF BODY MASS INDEX WITH CLOPIDOGREL RESISTANCE

Pakistan Journal of Physiology

Mudassar Noor²  Chaudhry Altaf³  Usman Nawaz⁴  Saleem Ahmad Khan⁵  Akbar Waheed⁶ 

[1] Dean Army Medical College, Professor of Pathology, National University of Medical Sciences (NUMS) Rawalpindi;Assistant Professor, Pharmacology Department Army Medical College, National University of Medical sciences (NUMS) Rawalpindi ;Consultant Hematologist, Armed Focres Institute of Pathology (AFIP), National University of Medical sciences (NUMS) Rawalpindi;PhD Scholar, Pharmacology Department, Amry Medical College, National University of Medical sciences (NUMS) Rawalpindi;Principal &Professor of Pharmacology and PhD supervisor, Pharmacology Department, Amry Medical College, National University of Medical sciences (NUMS) Rawalpindi

关键词: BMI;    clopidogrel responders;    clopidogrel resistance;    Pakistan;   

DOI  :  

学科分类：解剖和生理学

来源: Pakistan Physiological Society

【 摘 要 】

Background: Clopidogrel is an essential component of dual antiplatelet treatment for ischemic heart disease. We planned to explore the association of body mass index with clopidogrel resistance in ischemic heart disease patients. Methods: Three hundred and ninety patients of ischemic heart disease who were taking clopidogrel 75mg/day, were included in the study. Patients were categorized according to their body mass index (BMI) into underweight (BMI<18.50 Kg/m2), normal weight (BMI 18.50–22.99 Kg/m2), overweight (BMI 23.00–24.99 Kg/m2), and obese (BMI>25 Kg/m2). Their blood samples were taken and platelet aggregation studies were performed using Chronolog light transmission aggregometer to confirm clopidogrel resistant status. Results: None of the underweight, 19.50% of the normal weight, 24.20% of the overweight and 33.60% of the obese patients were found to be clopidogrel resistant. Clopidogrel resistance was significantly higher in obese patients as compared to normal weight patients, p=0.019. No significant difference in clopidogrel response was found between normal weight and overweight patients, as well as overweight and obese patients. Mean BMI of clopidogrel resistant patients was significantly higher than mean BMI of clopidogrel responders (26.46±3.82 vs 24.15±3.39 Kg/m2), p<0.001. Correlation between BMI and platelet aggregation was significant (p<0.001, r=0.20). Conclusion: BMI is inversely related to the platelet inhibition by clopidogrel. Higher BMI is related to clopidogrel resistance in ischemic heart disease patients.

【 授权许可】

CC BY