| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| Parainflammation, chronic inflammation, and age‐related macular degeneration | |
| 关键词: retina; blood‐; retina barrier; immune privilege; microglia; complement; | |
| DOI : 10.1189/jlb.3RI0615-239R | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
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【 摘 要 】
Inflammationisanadaptiveresponseoftheimmunesystemtonoxiousinsultstomaintainhomeostasisandrestorefunctionality.Theretinaisconsideredanimmune‐privilegedtissueasaresultofitsuniqueanatomicandphysiologicproperties.Duringaging,theretinasuffersfromalow‐gradechronicoxidativeinsult,whichsustainsfordecadesandincreasesinlevelwithadvancingage.Asaresult,theretinalinnate‐immunesystem,particularlymicrogliaandthecomplementsystem,undergoeslowlevelsofactivation(parainflammation).Inmanycases,thisparainflammatoryresponsecanmaintainhomeostasisinthehealthyagingeye.However,inpatientswithage‐relatedmaculardegeneration,thisparainflammatoryresponsebecomesdysregulatedandcontributestomaculardamage.Factorscontributingtothedysregulationofage‐relatedretinalparainflammationincludegeneticpredisposition,environmentalriskfactors,andoldage.Dysregulatedparainflammation(chronicinflammation)inage‐relatedmaculardegenerationdamagesthebloodretinabarrier,resultinginthebreachofretinal‐immuneprivilege,leadingtothedevelopmentofretinallesions.Thisreviewdiscussesthebasicprinciplesofretinalinnate‐immuneresponsestoendogenouschronicinsultsinnormalagingandinage‐relatedmaculardegenerationandexploresthedifferencebetweenbeneficialparainflammationandthedetrimentalchronicinflammationinthecontextofage‐relatedmaculardegeneration...
【 授权许可】
CC BY
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201904043739210ZK.pdf | 1641KB |  download |
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