| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| The rat NK cell receptors Ly49s4 and Ly49i4 recognize nonclassical MHC‐I molecules on Listeria monocytogenes‐infected macrophages | |
| 关键词: Ly49 receptors; infection; bacterial; | |
| DOI : 10.1189/jlb.1010593 | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
 PDF
|
|
【 摘 要 】
Ly49receptorsinrodents,likeKIRsinhumans,regulateNKcellactivity.AlthoughinhibitoryLy49receptorsclearlyrecognizeMHC‐Imolecules,ligandsfortheactivatingLy49receptorsarelesswelldefined.Here,weshowthattheactivatingLy49s4andtheinhibitoryLy49i4receptorsrecognizenonclassicalMHC‐ImoleculesontheratmacrophagecelllineR2(RT1d).ListeriainfectionofR2macrophagesledtoincreasedexpressionofclassicalandnonclassicalMHC‐Imolecules.CoincubationoftheseinfectedcellswithreportercellsexpressingLy49i4orLy49s4increasedthereportercellresponses.TheseresponseswereblockedbymAbOX18(anti‐MHC‐I)andAAS1(anti‐nonclassicalMHC‐I).IFN‐γtreatmentofnormalR2cellsalsoincreasedtheMHC‐Iexpressionandenhancedthereportercellresponses.TheseresultssuggestthatactivatingandinhibitoryLy49receptorsmonitorMHC‐IexpressiononListeria‐infectedcells...
【 授权许可】
CC BY
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201904043656968ZK.pdf | 1011KB |  download |
878987797
028-85220240
