| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| Extracellular ubiquitin: immune modulator and endogenous opponent of damage‐associated molecular pattern molecules | |
| 关键词: danger signals; CXCR4; inflammation; immunotherapy; | |
| DOI : 10.1189/jlb.0510316 | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
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【 摘 要 】
Ubiquitinisapost‐translationalproteinmodifierandplaysessentialrolesinallaspectsofbiology.Althoughthediscoveryofubiquitinintroducedthishighlyconservedproteinasamoleculewithextracellularactions,theidentificationofubiquitinastheATP‐dependentproteolysisfactor1hasfocusedsubsequentresearchonitsimportantintracellularfunctions.Littleattentionhassincebeenpaidtoitsroleoutsideofthecell.Duringrecentyears,multipleobservationssuggestthatextracellularubiquitincanmodulateimmuneresponsesandthatexogenousubiquitinhastherapeuticpotentialtoattenuateexuberantinflammationandorganinjury.Theseobservationshavenotbeenintegratedintoacomprehensiveassessmentofitspossibleroleasanendogenousimmunemodulator.Thisreviewrecapitulatesthecurrentknowledgeaboutextracellularubiquitinanddiscussesanemergingfacetofitsroleinbiologyduringinfectiousandnoninfectiousinflammation.ThesynopsisofthesedataalongwiththerecentidentificationofubiquitinasaCXCR4agonistsuggestthatextracellularubiquitinmayhavepleiotropicrolesintheimmunesystemandfunctionsasanendogenousopponentofDAMPs.Functionsofextracellularubiquitincouldconstituteanevolutionaryconservedcontrolmechanismaimedtobalancetheimmuneresponseandpreventexuberantinflammation.Furthercharacterizationofitsmechanismofactionandcellularsignalingpathwaysisexpectedtoprovidenovelinsightsintotheregulationoftheinnateimmuneresponseandopportunitiesfortherapeuticinterventions...
【 授权许可】
CC BY
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201904043645598ZK.pdf | 624KB |  download |
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