CCRL2 regulates M1/M2 polarization during EAE recovery phase

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: atypical chemokine receptors;    chemokines;    macrophages;    microglia;    inflammation;    multiple sclerosis;   

DOI  :  10.1189/jlb.3MA0915-444RR

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Chemokine(CCmotif)receptor‐like2isa7‐transmembraneproteinrelatedtothefamilyoftheatypicalchemokinereceptors,whichareproteinsdevoidofchemotacticactivityandinvolvedinthecontrolofinflammation.Experimentalautoimmuneencephalitisisanautoimmunedisorderthatreplicatestheinflammatoryaspectsofmultiplesclerosis.Chemokine(CCmotif)receptor‐like2–deficientmicedevelopedexacerbated,nonresolvingdiseasewithprotractedinflammatoryresponseandincreaseddemyelination.Theincreasedseverityofthediseasewasassociatedwithhigherlevelsofmicroglia/macrophageactivationmarkersandimbalancedM1/M2polarization.Thus,chemokine(CCmotif)receptor‐like2isinvolvedinthedownregulationofcentralnervoussystem–associatedexperimentalautoimmuneencephalitisinflammationintherecoveryphaseofthedisease.Thereforechemokine(CCmotif)receptor‐like2shouldbeconsideredtobeamoleculeinvolvedintheregulationoftheinflammatoryresponseassociatedwithmultiplesclerosis...

【 授权许可】

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