期刊论文详细信息
| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| NLRs, inflammasomes, and viral infection | |
| 关键词: caspase; RNA virus; DNA virus; innate immunity; | |
| DOI : 10.1189/jlb.0312132 | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
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【 摘 要 】
NLRproteinsareinnateimmunesensorsthatrespondtomicrobialinfection.Uponpathogeninfection,someNLRproteinsformlargecomplexes,calledinflammasomes,whichactivatecaspase‐1andinducetheproductionofactiveIL‐1βandIL‐18.Activationofinflammasomescanalsoleadtoaninflammatorycelldeathprogram,namedpyroptosis.Inthisreview,wewilldiscusstheroleofvariousNLRproteinsinsensingdifferentviralinfections,aswellasthestrategiesusedbyseveralRNAandDNAvirusestocounteracttheantiviraleffectsofNLR‐dependentinflammasomes...
【 授权许可】
CC BY
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201904043088846ZK.pdf | 879KB |  download |
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