Diminished responsiveness to human β‐defensin‐3 and decreased TLR1 expression on monocytes and mDCs from HIV‐1‐infected patients

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: antimicrobial peptide;    pattern recognition receptor;    costimulatory molecule;    antigen‐;    presenting cell;   

DOI  :  10.1189/jlb.1111555

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

hBD‐3isanantimicrobialpeptidethatmaycontributetoadaptiveimmuneresponsesbyactivatingprofessionalAPCsviaaTLR1/2‐dependentmechanism.PatientswithHIVdiseaseexperienceincreasedsusceptibilitytomucosalinfections,whichmay,inpart,stemfromdiminishedAPCfunction.OurcurrentstudiesdemonstrateareducedcapacityofhBD‐3toinducetheexpressionofacostimulatorymolecule,CD80,onmonocytesandmDCsfromHIV‐infectedpersonscomparedwithcellsfromhealthycontrols.AlthoughtheexpressionofTLR1andTLR2onmonocyteswasnotastrongpredictorofhBD‐3responsivenessinbivariateanalyses,monocytesandmDCsfromHIV‐infectedpersonsexpressedsignificantlylowerlevelsofTLR1.MonocyteexpressionoftheactivationmarkerCD69,incellsfromHIV‐infectedpersonswiththerapeuticallycontrolledviremia,wascorrelateddirectlywithTLR2andTLR4expressionbutnotwithTLR1expression.Overall,thesestudiessuggestthatimmuneactivationmayaffectTLR2andTLR4expressionbutmaynotfullyaccountforreducedTLR1expressioninmonocytesfromHIV‐infectedpersons.ImpairmentsinhBD‐3responsivenessandTLR1expressionarelikelytocontributetoincreasedriskofmucosalinfectioninHIVdisease...

【 授权许可】

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