| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| Inhibition of meningitis‐associated neutrophil apoptosis by TNF‐α depends on functional PI3‐kinase in monocytes | |
| 关键词: granulocyte; lifespan; cytokines; signaling; cell death; sepsis; | |
| DOI : 10.1189/jlb.0511218 | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
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【 摘 要 】
Inbacterialmeningitis,neutrophilscopewithbacterialinfectionbutalsoleadtotissuedamage.ThebalanceofbeneficialandharmfuleffectsmaydependonthelifespanoftheneutrophilsintheCNS.Here,weshowthatCSFofpatientswithmeningococcalmeningitiscontainsaneutrophilapoptosis‐inhibitingcapacitythatcorrelateswithTNF‐αcontent.InvitroexperimentsshowthatNeisseriameningitidisaswellasLPSderivedfromthesebacteriaregulatedneutrophilapoptosismainlybystimulatingTNF‐αproductioninmonocytes.WhereasLPS‐inducedPI3K‐dependentsurvivalsignalsinmonocytesarecriticalforneutrophilsurvival,PI3Ksignalingingranulocytesdidnotcontributetotheincreasedlifespanofneutrophils.WeconcludethatLPS‐drivenPI3Ksignalinginmonocytesregulatesneutrophilapoptosisandthereby,maybecrucialintheinitiationofsecondarybraindamageinbacterialmeningitis...
【 授权许可】
CC BY
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201904042791939ZK.pdf | 748KB |  download |
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