Myelin ingestion alters macrophage antigen‐presenting function in vitro and in vivo

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: monocytes;    Th1/Th2 cells;    antigen presentation/processing;    EAE/MS;    neuroimmunology;   

DOI  :  10.1189/jlb.1209813

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

DuringMS,phagocytosingmyelin‐containingmacrophagesariseandlieincloseproximitytoTcells.Todate,ithasnotbeenaddressedwhetherthesemyelin‐ladenmacrophageshavethecapacitytopresentantigenstoTcellsandwhetherthiscontributestoinflammationindisease.Wedemonstratethatinvitro‐generatedhumanandmousemyelin‐ladenmacrophagesexpressedMHCclassIandIIandcostimulatorymoleculesandarethuswellequippedforantigenpresentation.Humanmyelin‐ladenmacrophagesexhibitednormalendocytosisofparticulateandsolubleantigens.Inaddition,humanmyelin‐ladenmacrophageselicitedactiveTcellproliferationofnaïveaswellasmemoryTcells.Furthermore,mousemyelin‐ladenmacrophagesinducedprimaryantigen‐specificCD4+TcellproliferationinvivobuttransientlydiminishedIFN‐γrelease.Functionally,MOGpeptide‐loadedmyelin‐ladenmousemacrophagesmodestlybutsignificantlyreducedtheseverityofMOGpeptide‐inducedEAE.Thesedatashowthatmyelinuptakeresultsintheinductionofapopulationofmacrophagesthatretainsantigen‐presentingcapacityandlimitsautoimmune‐mediateddisease...

【 授权许可】

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