A synthetic peptide derived from the parasite Toxoplasma gondii triggers human dendritic cellsˈ migration

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: ESA;    GRA5;    CCR7;    synthetic peptide;   

DOI  :  10.1189/jlb.1211600

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

ThemigrationofDCsisacriticalfunction,enablinginformationtobecarriedtowheretheimmunologicalresponseoccurs.ParasitesareknowntoweakenhostimmunitybyinterferingwiththefunctionsofDCsandthus,maybeasourceofmoleculeswithimmunomodulatoryproperties.Here,wedemonstratethatthesolubleprotein,GRA5,specifictoToxoplasmagondii,isabletoincreasethemigrationofhumanCD34‐DCstowardCCL19.AsyntheticPep29derivedfromtheGRA5hydrophilicNTregion(Pep29)wasfoundtobeinternalizedbymacropinocytosisandtotriggerinvitromigrationofCD34‐DCsviaCCR7expressionwithoutactivatingDCs.Pep29alsoinducedadecreaseinthenumberofLCsfromhumanskinepidermis.AslocaldepletionofDCsandmigrationofimmatureDCsleadtoadisruptionofthespecificinnateresponse,ourresultshighlightthepotentialofusingpathogen‐derivedsyntheticpeptidesasnovelcellmodulatorswithatherapeuticpotentialtoreducesymptomsininflammatorydisorders...

【 授权许可】

CC BY