| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| Inflammatory mechanisms in ischemic stroke: role of inflammatory cells | |
| 关键词: inflammation; leukocytes; brain ischemia; | |
| DOI : 10.1189/jlb.1109766 | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
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【 摘 要 】
Inflammationplaysanimportantroleinthepathogenesisofischemicstrokeandotherformsofischemicbraininjury.Experimentallyandclinically,thebrainrespondstoischemicinjurywithanacuteandprolongedinflammatoryprocess,characterizedbyrapidactivationofresidentcells(mainlymicroglia),productionofproinflammatorymediators,andinfiltrationofvarioustypesofinflammatorycells(includingneutrophils,differentsubtypesofTcells,monocyte/macrophages,andothercells)intotheischemicbraintissue.Thesecellulareventscollaborativelycontributetoischemicbraininjury.Despiteintenseinvestigation,therearestillnumerouscontroversiesconcerningthetimecourseoftherecruitmentofinflammatorycellsinthebrainandtheirpathogenicrolesinischemicbraininjury.Inthisreview,weprovideanoverviewofthetime‐dependentrecruitmentofdifferentinflammatorycellsfollowingfocalcerebralI/R.Wediscusshowthesecellscontributetoischemicbraininjuryandhighlightcertainrecentfindingsandcurrentlyunansweredquestionsaboutinflammatorycellsinthepathophysiologyofischemicstroke...
【 授权许可】
CC BY
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201904042330663ZK.pdf | 297KB |  download |
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