Th22 cells are expanded in multiple sclerosis and are resistant to IFN‐β

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: cytokines;    interferons;    interferon receptors;    CD4 T helper cells;    human;    autoimmunity;   

DOI  :  10.1189/jlb.5A0813-463RR

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Th1andTh17cellshavebeenconsideredaseffectorsinmouseEAEandinthehumancounterpart,MS.Recently,IL‐22,aTh17‐related,proinflammatorycytokine,hasbeenassociatedwithanewThcellsubset,definedasTh22,involvedinchronicinflammatoryconditions,suchaspsoriasis;theroleofIL‐22inMShasnotyetbeenelucidated.Here,wereportthatsimilartoTh17cells,thenumberofTh22cellsincreasedinthePBandtheCSFofRRMSpatients,especiallyduringtheactivephasesofthedisease.However,asopposedtoTh17cells,theexpansionofTh22cellsoccurredbeforetheactivephasesofthedisease.Th22cellswerefoundtobespecificfortheautoantigenMBPandalsoexpressedhighlevelsofCCR6andT‐bet,asforTh17cells,indicatingthatTh22self‐reactivecellscouldhaveCNS‐homingpropertiesandbepathogenicinactiveRRMSpatients.ConverselytoTh17cells,Th22cellsdisplayedlowerlevelsofIFNAR1andwereinsensitivetoIFN‐βinhibition.ThesedatasuggestthatexpansionofTh22cellsinMScouldbeoneofthefactorsthatcriticallyinfluenceresistancetoIFN‐βtherapy...

【 授权许可】

CC BY