| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| Potential mechanisms regulating pulmonary pathology in inflammatory bowel disease | |
| 关键词: lung; neutrophil; homing; T cells; microbiome; | |
| DOI : 10.1189/jlb.3RU1114-563R | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
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【 摘 要 】
Inflammatoryboweldiseaseisassociatedwithanumberofcomorbiditiesthatariseatextraintestinalsites,includingthelung.Pulmonarymanifestationsreportedininflammatoryboweldiseaseincludebronchiectasis,chronicbronchitisandimportantly,arangeofsubclinicalrespiratoryabnormalitiesthatareoftenoverlookedinroutineclinicalevaluation.WhereasevidenceforthepulmonarymanifestationsofInflammatoryboweldiseaseisincreasing,littleisknownabouttheimmunologicandphysiologicmechanismsregulatingcross‐talkbetweenthegutandlungduringdisease.ThisreviewexaminesreportedlunginvolvementinInflammatoryboweldiseaseanddiscussesthepossibleimmunepathwaysthatunderliepulmonarypathologies.Thesemechanismsincludedysfunctionalimmune‐cellhoming,systemicinflammation,andmicrobialdysbiosis;allofwhichmaycontributetoInflammatoryboweldisease‐inducedpulmonaryinflammation.ThesemechanismsarediscussedinthecontextofourcurrentknowledgeofthesharedmucosalimmunesystemandtheimmunologyofInflammatoryboweldisease...
【 授权许可】
CC BY
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201904041875059ZK.pdf | 955KB |  download |
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