期刊论文详细信息
| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| Translating DRiPs: MHC class I immunosurveillance of pathogens and tumors | |
| 关键词: antigen processing; cotranslational degradation; translation; ribosome; compartmentalization; nuclear translation; | |
| DOI : 10.1189/jlb.1113599 | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
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【 摘 要 】
MHCclassImoleculesdisplayoligopeptidesonthecellsurfacetoenableTcellimmunosurveillanceofintracellularpathogensandtumors.Speedisoftheessenceindetectingviruses,whichcancompleteafullreplicationcycleinjusthours,whereastumordetectionistypicallyafinding‐the‐needle‐in‐the‐haystackexercise.Wereviewcurrentevidencesupportinganonrandom,compartmentalizedselectionofpeptidogenicsubstratesthatfocusesonrapidlydegradedtranslationproductsasamainsourceofpeptideprecursorstooptimizeimmunosurveillanceofpathogensandtumors...
【 授权许可】
CC BY
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201904041570066ZK.pdf | 313KB |  download |
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