Genetic Variants in Toll-Like Receptor 4 Gene and Their Association Analysis with Estimated Glomerular Filtration Rate in Mexican American Families

Cardiorenal medicine

Farook Thameem ; Sobha Puppala ; Vidya S. Farook ; Balakuntalam S. Kasinath ; John Blangero ; Ravindranath Duggirala ; Hanna E. Abboud

关键词: Toll-like receptor 4;    Asp(299)Gly;    Thr(399)Ile;    rs4986790;    rs4986791;    Estimated glomerular filtration rate;    Mexican Americans;   

DOI  :  10.1159/000445754

学科分类：心脏病和心血管学

来源: S Karger AG

【 摘 要 】

Abstract Background/Aim: Toll-like receptor 4 (TLR4) is one of the regulators of the innate immune response. Genetic variations in TLR4 have been associated with inflammatory diseases, including type 2 diabetes. However, to our knowledge, there are no reports on the role of variations in TLR4 in chronic kidney disease susceptibility. The objective of this study is to determine whether the genetic variants in TLR4 are associated with the estimated glomerular filtration rate (eGFR), a measure of r.

【 授权许可】

CC BY