The multifaceted nature of NLRP12

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: Nod‐;    like receptors;    NF‐;    κ;    B;    inflammasome;    infection;    cancer;   

DOI  :  10.1189/jlb.3RU0514-265RR

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

NLRsareaclassofcytoplasmicPRRswithvariousfunctions,rangingfrompathogen/damagesensingtothemodulationofinflammatorysignalingandtranscriptionalcontrolofMHCandrelatedgenes.Inaddition,someNLRshavebeenimplicatedinpreimplantationandprenataldevelopment.NLRP12(alsoknownasRNO,PYPAF7,andMonarch‐1),amemberofthefamilycontaininganN‐terminalPYD,aNBD,andaC‐terminalLRRregion,isoneofthefirstdescribedNLRproteinswhoseroleremainscontroversial.TheinteresttowardNLRP12hasbeenboostedbyitsrecentinvolvementincoloncancer,aswellasintheprotectionagainstsomesevereinfections,suchasthatinducedbyYersiniapestis,thecausativeagentofplague.AsNLRP12ismainlyexpressedbytheimmunecells,anditsexpressionisdown‐regulatedinresponsetopathogenproductsandinflammatorycytokines,ithasbeenpredictedtoplayaroleasanegativeregulatoroftheinflammatoryresponse.Herein,wepresentanoverviewoftheNLRfamilyandsummarizerecentinsightsonNLRP12addressingitscontributiontoinflammatorysignaling,hostdefense,andcarcinogenesis...

【 授权许可】

CC BY