Regulation of inflammation by cannabinoids, the endocannabinoids 2‐arachidonoyl‐glycerol and arachidonoyl‐ethanolamide, and their metabolites

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: MAG lipase;    anandamide;    prostaglandin;    leukotriene;    leukocyte;    eicosanoid;   

DOI  :  10.1189/jlb.3RU0115-021R

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

2‐Arachidonoyl‐glycerol(2‐AG)andarachidonyl‐ethanolamide(AEA)areendocannabinoidsthathavebeenimplicatedinmanyphysiologicdisorders,includingobesity,metabolicsyndromes,hepaticdiseases,pain,neurologicdisorders,andinflammation.Theirimmunomodulatoryeffectsarenumerousandarenotalwaysmediatedbycannabinoidreceptors,reflectingthepresenceofanarachidonicacid(AA)moleculeintheirstructure,thelatterbeingtheprecursorofnumerousbioactivelipidsthatarepro‐oranti‐inflammatory.2‐AGandAEAcanthusserveasasourceofAAbutcanalsobemetabolizedbymosteicosanoidbiosyntheticenzymes,yieldingadditionallipids.Inthisregard,enhancingendocannabinoidlevelsbyusingendocannabinoidhydrolysisinhibitorsislikelytoaugmentthelevelsoftheselipidsthatcouldregulateinflammatorycellfunctions.ThisreviewsummarizesthemetabolicpathwaysinvolvedinthebiosynthesisandmetabolismofAEAand2‐AG,aswellasthebiologiceffectsofthe2‐AGandAEAlipidomesintheregulationofinflammation...

【 授权许可】

CC BY