Unraveling the complexity of lipid body organelles in human eosinophils

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: lipid droplets;    inflammation;    eicosanoids;    immune responses;    cell activation;    electron microscopy;   

DOI  :  10.1189/jlb.3RU0214-110R

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Lipid‐richorganellesarecommoninmanycelltypes.Incells,suchasadipocytes,theseorganellesaretermedLDs,whereasinothercells,suchasleukocytes,theyarecalledLBs.ThestudyofleukocyteLBshasattractedattentionasaresultoftheirassociationwithhumandiseases.Inleukocytes,suchaseosinophils,LBaccumulationhasbeendocumentedextensivelyduringinflammatoryconditions.Inthesecells,LBsarelinkedtotheregulationofimmuneresponsesbycompartmentalizationofseveralproteinsandlipidsinvolvedinthecontrolandbiosynthesisofinflammatorymediators(eicosanoids).However,ithasbeenunclearhowdiverseproteins,includingmembrane‐associatedenzymesinvolvedineicosanoidformation,incorporateintoLBs,especiallyiftheinternalcontentofLBsisassumedtoconsistsolelyofstoresofneutrallipids,aspresentwithinadipocyteLDs.Studiesoftheformation,function,andultrastructureofLBsineosinophilshavebeenprovidinginsightspertinenttoLBsinotherleukocytes.Here,wereviewcurrentknowledgeofthecompositionandfunctionofleukocyteLBsasprovidedbystudiesofhumaneosinophilLBs,includingrecognitionsoftheinternalarchitectureofeosinophilLBsbasedon3Delectrontomographicanalyses...

【 授权许可】

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