| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| Sphingosine‐1‐phosphate suppresses TLR‐induced CXCL8 secretion from human T cells | |
| 关键词: CD4+ T cells; Toll‐; like receptors; serum lipids; S1P; | |
| DOI : 10.1189/jlb.0712328 | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
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【 摘 要 】
TcellsproduceanumberofcytokinesandchemokinesuponstimulationwithTLRagonistsinthepresenceorabsenceofTCRsignals.Here,weshowthatsecretionofneutrophilchemoattractantCXCL8fromhumanTcelllineJurkatinresponsetostimulationwithTLRagonistsisreducedwhencellstimulationiscarriedoutinpresenceofserum.Serumdoesnot,however,inhibitTCR‐activatedsecretionofCXCL8nordoesitdown‐regulateTLR‐costimulatedIL‐2secretionfromactivatedTcells.ThemoleculethatcanmimictheabilitytobringaboutsuppressioninCXCL8fromTLR‐activatedTcellsisserum‐bornebioactivelipid,S1P.SerumandS1P‐mediatedinhibitionrequireintracellularcalcium.S1PalsosuppressesCXCL8secretionfromperipheralblood‐derivedhumanTcellsactivatedexvivowithvariousTLRligands.OurfindingsrevealapreviouslyunrecognizedroleforS1PinregulatingTLR‐inducedCXCL8secretionfromhumanTcells...
【 授权许可】
CC BY
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201904041232063ZK.pdf | 490KB |  download |
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