Glycobiology simplified: diverse roles of glycan recognition in inflammation

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: selectin;    siglec;    galectin;    lectin;    sialic acid;    fucose;   

DOI  :  10.1189/jlb.3RI0116-021R

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Glycansandcomplementaryglycan‐bindingproteinsareessentialcomponentsinthelanguageofcell‐cellinteractionsinimmunity.Thestudyofglycanfunctionisthepurviewofglycobiology,whichhasoftenbeenpresentedasanunusuallycomplexdiscipline.Infact,thehumanglycome,composedofallofitsglycans,isbuiltprimarilyfromonly9buildingblocksthatarecombinedbyenzymes(writers)withspecificandlimitedbiosyntheticcapabilitiesintoatractableandincreasinglyaccessiblenumberofpotentialglycanpatternsthatarefunctionallyreadbyseveraldozenhumanglycan‐bindingproteins(readers).Nowhereistheimportanceofglycanrecognitionbetterunderstoodthanininfectionandimmunity,andknowledgeinthisareahasalreadyledtoglycanmimeticanti‐infectiveandanti‐inflammatorydrugs.Thisreviewincludesabrieftutorialonhumanglycobiologyandalimitednumberofspecificexamplesofglycan‐bindingprotein‐glycaninteractionsthatinitiateandregulateinflammation.Examplesincluderepresentativesfromdifferentglycan‐bindingproteinfamilies,includingtheC‐typelectins(E‐selectin,P‐selectin,dectin‐1,anddectin‐2),sialicacid‐bindingimmunoglobulin‐likelectins(sialicacid‐bindingimmunoglobulin‐likelectins8and9),galectins(galectin‐1,galectin‐3,andgalectin‐9),aswellashyaluronicacid‐bindingproteins.Asglycosciencetechnologiesadvance,opportunitiesforenhancedunderstandingofglycansandtheirrolesinleukocytecellbiologyprovideincreasingopportunitiesfordiscoveryandtherapeuticintervention...

【 授权许可】

CC BY