| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| Interleukin‐27 and interleukin‐23 modulate human plasmacell functions | |
| 关键词: cytokines; cytokine receptors; B lymphocytes; | |
| DOI : 10.1189/jlb.1210660 | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
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【 摘 要 】
ThisstudytestedthehypothesisthatIL‐27andIL‐23,twoheterodimericcytokinesinvolvedinphysiologicalimmuneresponsesandimmunologicaldisorders,mayfunctiononhumanPCandplasmablasts.ItwasreportedthatIL‐27actsonhumanmatureBcells,buttheroleofIL‐27andIL‐23inhumanPCremainstobeestablished.Thus,wehaveaskedwhetherthesecytokinesmaymodulatehumanPCfunctionsusinghumanPPCgeneratedinvitro,PCisolatedfromtonsils,andBM.Here,weshowforthefirsttimethatPCandPPCexpresscompleteIL‐27RandthatIL‐27exertschemotacticpropertiesonthesecellsandmodulatesdifferentchemokines/chemokinereceptorsandsecretionofIgMandIgG.Furthermore,wedemonstratedthatPCandPPCexpressbothchainsofIL‐23RandIL‐23andexertedsimilaractivitytoIL‐27intermsofIgproduction,whilenotinducingPCchemotaxis.TheseresultsmayprovidenovelinsightintotheroleofIL‐27andIL‐23inhumanBcellimmuneresponses...
【 授权许可】
CC BY
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201904040884951ZK.pdf | 875KB |  download |
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