Macrophage responses to implants: prospects for personalized medicine

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: cytokine;    biomarker;    biomaterial;    titanium;    coating;   

DOI  :  10.1189/jlb.5VMR0415-166R

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Implants,transplants,andimplantablebiomedicaldevicesaremainstreamsolutionsforawidevarietyofhumanpathologies.Oneofthepersistentproblemsaroundnondegradablemetallicandpolymericimplantsisfailureofmacrophagestoresolvetheinflammationandtheirtendencytostayinastate,named“frustratedphagocytosis.”Duringtheinitialphase,proinflammatorymacrophagesinduceacutereactionstotraumaandforeignmaterials,whereastolerogenicanti‐inflammatorymacrophagescontrolresolutionofinflammationandinducethesubsequenthealingstage.However,implantedmaterialscaninduceamixedpro/anti‐inflammatoryphenotype,supportingchronicinflammatoryreactionsaccompaniedbymicrobialcontaminationandresultinginimplantfailure.Severalmaterialsbasedonnaturalpolymersforimprovedinteractionwithhosttissueorsurfacesthatreleaseanti‐inflammatorydrugs/bioactiveagentshavebeendevelopedforimplantcoatingtoreduceimplantrejection.However,nodefinitive,long‐termsolutiontoavoidadverseimmuneresponsestotheimplantedmaterialsisavailabletodate.Thepreventionofimplant‐associatedinfectionsorchronicinflammationbymanipulatingthemacrophagephenotypeisapromisingstrategytoimproveimplantacceptance.Theimmunomodulatorypropertiesofcurrentlyavailableimplantcoatingsneedtobeimprovedtodeveloppersonalizedtherapeuticsolutions.Humanprimarymacrophagesexposedtotheimplantablematerialsexvivocanbeusedtopredicttheindividual'sreactionsandallowselectionofanoptimalcoatingcomposition.Ourreviewdescribescurrentunderstandingofthemechanismsofmacrophageinteractionswithimplantablematerialsandoutlinestheprospectsforuseofhumanprimarymacrophagesfordiagnosticandtherapeuticapproachestopersonalizedimplanttherapy...

【 授权许可】

CC BY