| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| Novel roles of reactive oxygen species in the pathogenesis of acute myeloid leukemia | |
| 关键词: ROS; cell signaling; leukemogenesis; | |
| DOI : 10.1189/jlb.0113006 | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
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【 摘 要 】
IthasbecomeapparentthatregulationofROSisimportantincellsignalingandhomeostasis.AccumulationofROStriggersoxidativestressinvariouscelltypesandcontributestothedevelopment,progression,andpersistenceofcancer.RecentresearchhasdemonstratedthatredoxdysregulationcausedbyROSpromotesproliferation,differentiation,genomic,andepigeneticalterations;immuneevasion;andsurvivalinleukemiccells.ROSactassignalingmoleculestoregulateredox‐sensitivetranscriptionalfactors,enzymes,oncogenes,andotherdownstreameffectors.Thus,athoroughunderstandingtheroleofROSaskeymediatorsinleukemogenesisislikelytoprovideopportunitiesforimprovedpharmacologicalintervention.Inthisreview,wesummarizetherecentfindingsthatsupportaroleforROSinthepathogenesisofAMLandoutlineinnovativeapproachesintheimplementationofredoxtherapiesformyeloidmalignancies...
【 授权许可】
CC BY
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201904040296921ZK.pdf | 1038KB |  download |
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