Effect of bacillus Calmette‐Guérin vaccination on CD4+Foxp3+ T cells during acquired immune response to Mycobacterium tuberculosis infection

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: Tregs;    BCG vaccination;    inflammation;   

DOI  :  10.1189/jlb.4A0614-308RR

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

IncreasinginformationhasshownthatmanynewlyemergingstrainsofMycobacteriumtuberculosis,includingthehighlyprevalentandtroublesomeBeijingfamilyofstrains,canpotentlyinducetheemergenceofFoxp3+CD4Tregs.Althoughthesignificanceofthisisstillnotfullyunderstood,wehavepreviouslyprovidedevidencethattheemergenceofthispopulationcansignificantlyablatetheprotectiveeffectofBCGvaccination,causingprogressivefataldiseaseinthemousemodel.However,whetherthepurposeofthisresponseistocontrolinflammationortodirectlydampentheacquiredimmuneresponseisstillunclear.Inthepresentstudy,wehaveshown,usingbothcelldepletionandadoptivetransferstrategies,thatTregscanhaveeitherproperties.Celldepletionresultedinarapid,buttransient,decreaseinthelungbacterialload,suggestingreleaseortemporaryre‐expansionofeffectorimmunity.TransferofTregsintoRag2−/−ormarkedcongenicmiceworsenedthediseasecourseanddepressedcellularinfluxofeffectorTcellsintothelungs.Tregsfrominfecteddonorsseemedtopreferentiallydepresstheinflammatoryresponseandgranulocyticinflux.Incontrast,thosefromBCG‐vaccinatedandthenchallengeddonorsseemedmorefocusedondepressionofacquiredimmunity.ThesequalitativedifferencesmightberelatedtoincreasingknowledgereflectingtheplasticityoftheTregresponse...

【 授权许可】

CC BY