American Journal of Neurodegenerative Disease | |
Anti-inflammatory therapies of amyotrophic lateral sclerosis guided by immune pathways | |
Larry Lam1  | |
关键词: Amyotrophic lateral sclerosis; immune pathways; tocilizumab; hepatic fibrosis; vitamin E; | |
DOI : | |
学科分类:精神健康和精神病学 | |
来源: e-Century Publishing Corporation | |
【 摘 要 】
Sporadic ALS patients display heterogeneous immune pathways in peripheral blood mononuclear cells (PBMCs). We tested nine sALS patients and one unaffected identical twin of an index case by RNA-Seq of PBMCs. The inflammatory patients (n = 3) clustered into a subset with an inflammatory Th1/Th17 signature and the non-inflammatory patients (n = 7) into another subset with a B cell signature. The inflammatory subset was remarkable for granulocyte and agranulocyte diapedesis, hepatic fibrosis, roles of cytokines and metalloproteases. The non-inflammatory subset was highlighted by degradation of vitamin E, serotonin and nucleotides, altered T cell and B cell signaling, agranulocyte diapedesis, and up regulation of B cell genes. Identification of these differentially regulated pathways in sALS patients may guide the choice of anti-inflammatory therapies.
【 授权许可】
CC BY-NC
【 预 览 】
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RO201904039957400ZK.pdf | 2177KB | download |