Where Does the Alignment Score Distribution Shape Come from?

Evolutionary Bioinformatics

Philippe Ortet¹ 

关键词: sequence alignment scores;    Karlin-Altchul theorem;    mutual information;    sequence space;   

DOI  :  10.4137/EBO.S5875

学科分类：生物技术

来源: Sage Journals

【 摘 要 】

Alignment algorithms are powerful tools for searching for homologous proteins in databases, providing a score for each sequence present in the database. It has been well known for 20 years that the shape of the score distribution looks like an extreme value distribution. The extremely large number of times biologists face this class of distributions raises the question of the evolutionary origin of this probability law.

【 授权许可】

Unknown