Immunological Profile in Patients with Lupus Nephritis and Correlations with the Histological Pattern

Current Health Sciences Journal

DRAKOULOGKONA OURANIAreplacement¹ 

关键词: lupus nephritis;    autoantibody profile;    renal biopsy;   

DOI  :  10.12865/CHSJ.37.04.02

学科分类：医学（综合）

来源: Universitatea de Medicina si Farmacie din Craiova / University of Medicine and Pharmacy

【 摘 要 】

Lupus nephritis (LN) is a common manifestation in patients with systemic lupus erythematosus (SLE). Certain serum autoantibodies are associated with the presence of nephritis. Objective. The aim of the study is to describe and analyse the immunological antibody profile associated with the development of nephritis in patients with systemic lupus erythematosus and to find possible correlations with the histological pattern. Patients and methods. We designed a retrospective case control study of 61 patients with biopsy proven LN and 110 patients with SLE without LN. We used standard methods for laboratory testing of anti-dsDNA, anti-ENA and anti-phospholipid antibodies. Results. Patients with LN were significantly younger at the time of diagnosis ((26.4 (6.4) years versus 35.2 (10.6) years; p<0.001)  A higher frequency of anti-dsDNA, anti-Sm and LA was seen in the group with nephritis (p=0.002; p=0.005; p=0.0001).There were no significant correlations with gender, or the tipe of WHO h.

【 授权许可】

Unknown