Letalidad en hospitalizados por neumonía adquirida en la comunidad según antibiótico inicial. Estudio comparativo de dos series de casos

MEDISUR

Mercedes Corona Fonseca¹  Pedro Luis Ocampo Miralles²  Sandra Borroto Lecuna²  Iris González Morales²  Luis Alberto Corona Martínez³ 

[1] Facultad de Ciencias Médicas. Cienfuegos.;Hospital General Universitario Dr. Gustavo Aldereguía Lima. Cienfuegos.;Hospital Universitario General Dr. Gustavo Aldereguia Lima. Cienfuegos.

关键词: infecciones comunitarias adquiridas;    letalidad;    antiinfecciosos;   

DOI  :  

学科分类：医学（综合）

来源: Centro Provincial de Informacion de Ciencias Medicas de Cinfuegos

【 摘 要 】

Background:community-acquired pneumonia is one of the major health problems worldwide and in the hospital of Cienfuegos.Objective:to determine the changes in the relationship between the type of antimicrobial agent used empirically at admission and case fatality for community-acquired pneumonia in two case series designed at different times.Methods:an observational, descriptive study was conducted to compare two case series of patients hospitalized due to the condition under study. The relationship between the antimicrobial agents selected (amoxicillin/sulbactam, cefuroxime, ceftriaxone and cefotaxime) and case fatality was analyzed taking into account potentially confounding variables. In the statistical analysis, the Chi-square test was used to compare the proportions, and Fisher's exact test was applied, with a 95% confidence level (p <.05). Results:in the two case series, the same pattern was observed in terms of the antimicrobial agents associated with the lowest and highest case fatality: cefuroxime and cefotaxime, respectively. In contrast to the A series, the B series showed a more uniform behavior of case fatality with the use of the antimicrobials selected, which meant a considerable reduction in case fatality among patients treated initially with third-generation cephalosporins in the B series. In this sense, the most significant impact on case fatality was observed in patients receiving ceftriaxone.Conclusions:cefuroxime remains the initial empirical antimicrobial agent associated with the lowest case fatality among patients with community-acquired pneumonia. In the second case series, a clear reduction in case fatality was found in patients treated with ceftriaxone and cefotaxime.

【 授权许可】

CC BY