An eco-friendly procedure for the efficient synthesis of arylidinemalononitriles and 4,4′-(arylmethylene)bis(3-methyl-1-phenyl-1H-pyrazol-5-ols) in aqueous media

Green Chemistry Letters and Reviews

Moustafa A. Gouda¹ 

关键词: dual activation;    lithium hydroxide monohydrate;    knoevenagel condensation;    4;    4′-(arylmethylene)bis(3-methyl-1-phenyl-1H-pyrazol-5-ols);    arylidenemalononitrile;   

DOI  :  10.1080/17518253.2011.613858

学科分类：化学（综合）

来源: Taylor & Francis

【 摘 要 】

Commercially available lithium hydroxide monohydrate (LiOH·H2O) was found to be a novel “dual activation” catalyst for Knoevenagel condensation between malononitrile (1) or 3-methyl 1-phenyl-1H-pyrazol-5-(4H)-one (6) with aromatic aldehydes 2a–e leading to an efficient and easy synthesis of arylidenemalononitriles 3a–d and 4,4′-(arylmethylene)bis(3-methyl-1-phenyl-1H-pyrazol-5-ols) 7a–c in short times. The reaction of aryl aldehydes with malononitrile afforded excellent yields after 1–6 min in aqueous media at room temperature. In case of 3-methyl-1-phenyl-1H-pyrazol-5-(4H)-one (6) and aromatic aldehydes afforded good yields after 60–75 min at 90°C.

【 授权许可】

Unknown