The effect of levosimendan on myocardial ischemia–reperfusion injury in streptozotocin-induced diabetic rats

Libyan journal of medicine

Hasan Ali Kiraz¹ 

关键词: ischemia–reperfusion;    levosimendan;    myonecrosis;    inflammatory cell infiltration;    diabetic rat;   

DOI  :  10.3402/ljm.v10.29269

学科分类：医学（综合）

来源: Co-Action Publishing

【 摘 要 】

ObjectiveIschemia/reperfusion (I/R) injury is an important cause of myocardial damage by means of oxidative, inflammatory, and apoptotic mechanisms. The aim of the present study was to examine the potential cardio protective effects of levosimendan in a diabetic rat model of myocardial I/R injury.MethodsA total of 18 streptozotocin-induced diabetic Wistar Albino rats (55 mg/kg) were randomly divided into three equal groups as follows the diabetic I/R group (DIR) in which myocardial I/R was induced following left thoracotomy, by ligating the left anterior descending coronary artery for 60 min, followed by 2 h of reperfusion; the diabetic I/R levosimendan group (DIRL), which underwent I/R by the same method while taking levosimendan intraperitoneal 12 µg kg−1; and the diabetic control group (DC) which underwent sham operations without tightening of the coronary sutures. As a control group (C), six healthy age-matched Wistar Albino rats underwent sham operations similar to the DC group. Two hours after the ...

【 授权许可】

CC BY