Infection-resistant MRI-visible scaffolds for tissue engineering applications

BioImpacts

Mahmoudi M¹ 

关键词: Antibacterial properties;    Collagen scaffold;    Magnetic resonance imaging;    SPION;    Superparamagnetic iron oxide nanoparticles;    Tissue engineering;   

DOI  :  10.15171/bi.2016.16

学科分类：农业科学（综合）

来源: Tabriz University of Medical Sciences and Health Services

【 摘 要 】

Tissue engineering utilizes porous scaffolds as template to guide the new tissue growth. Clinical application of scaffolding biomaterials is hindered by implant-associated infection and impaired in vivo visibility of construct in biomedical imaging modalities. We recently demonstrated the use of a bioengineered type I collagen patch to repair damaged myocardium.By incorporating superparamagnetic iron oxide nanoparticles into this patch, here, we developed an MRI-visible scaffold. Moreover, the embedded nanoparticles impeded the growth of Salmonella bacteria in the patch. Conferring anti-infection and MRI-visible activities to the engineered scaffolds can improve their clinical outcomes and reduce the morbidity/mortality of biomaterial-based regenerative therapies.

【 授权许可】

CC BY