APhL antibody ELISA as an alternative to anticardiolipin test for the diagnosis of antiphospholipid syndrome

International Journal of Clinical and Experimental Pathology

Brenda B Suh-Lailam¹ 

关键词: Anticardiolipin;    APhL;    antiphospholipid antibodies;    method comparison;   

DOI  :  

学科分类：生理学与病理学

来源: e-Century Publishing Corporation

【 摘 要 】

BackgroundPersistent levels of antiphospholipid (aPL) antibodies [lupus anticoagulant (LA), anticardiolipin (aCL), anti-beta 2 glycoprotein I (aβ2GPI) IgG and/or IgM] in association with clinical features of thrombosis and/or pregnancy associated morbidity are indicative of antiphospholipid syndrome (APS). Of the aPL antibodies, aCL is the most sensitive for APS, however, their lack of specificity constitute a laboratory and clinical challenge. IgG/IgM antibodies directed against APhL (a mixture of phospholipids) has been reported to predict APS more reliably than aCL tests. The main objective of this study was to evaluate the performance characteristics of the APhL IgG/IgM ELISA, relative to the aCL and aβ2GPI tests.

【 授权许可】

CC BY-NC