Synthesis of 4‐(2‐Amino)ethoxy‐3′,4′‐dihydroxychalcones and Their Antioxidant and Cytotoxic Effects on Human Tumor Cells

Bulletin of the Korean Chemical Society

Changbae Jin¹  Jung Kim¹  Hye Jin Kim¹  Dong Woon Kim²  Seung Hwan Kim²  Sang Hoon Park³  Yong Sup Lee³  Kilwoong Mo⁴  Nam‐⁴  Hyoung Ja Kim⁵  Young Hun Lee⁵ 

[1] 701 Korea;791 Korea;Department of Life and Nanopharmaceutical Sciences Kyung Hee University Seoul 130‐Medicinal Chemistry Laboratory, Department of Pharmacy, College of Pharmacy Kyung Hee University Seoul 130‐Molecular Recognition Research Center, Future Convergence Research Division Korea Institute of Science and Technology Seoul 136‐

关键词: Chalcone;    Aminoethyl;    Antioxidant;    Cytotoxicity;    Solubility;   

DOI  :  10.1002/bkcs.10253

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

Recently, many reports revealed that there are close correlations between antioxidant and anticancer activities of compounds. In this study, we designed 4‐hydroxy‐3′,4′‐dihydroxychalcone (2) as a ring‐opened analog of luteolin, which has been known to possess both antioxidant and anticancer activities, and then introduced aminoethyl moieties to this chalcone structure to increase water solubility by transforming into HCl salts. Synthesized aminoalkyl‐substituted chalcones 3a–3d showed potent antioxidant activities in three different assay systems and anticancer activities against four tumor cell lines tested.

【 授权许可】

Unknown