Determination of iNOS-2087A>G Polymorphism in Acute Pancreatitis Patients

Current Health Sciences Journal

V. PADUREANUreplacement¹ 

关键词: acute pancreatitis;    polymorphism;    genotype;    iNOS;   

DOI  :  10.12865/CHSJ.40.04.03

学科分类：医学（综合）

来源: Universitatea de Medicina si Farmacie din Craiova / University of Medicine and Pharmacy

【 摘 要 】

Purpose To determine whether single nucleotide polymorphism (SNP) of inducible nitric oxide synthase (iNOS) is involved in susceptibility for acute pancreatitis. Material and Methods Genomic DNA was extracted from blood samples collected from cases of acute pancreatitis (n=110) and normal population controls frequency matched for age and sex (n=232). iNOS – 2087A>G polymorphism was genotyped using TaqMan allelic discrimination assays. The association of the genetic polymorphism with clinical and pathological data of the patients was evaluated. Results We have found no significant statistical association between this polymorphism and an increased risk of developing acute pancreatitis. Conclusion In Romanian population, the risk of developing acute pancreatitis is not increased by the presence of iNOS-2087A>G polymorphism.

【 授权许可】

Unknown