Solvent-free reactivity in the undergraduate organic laboratory

Green Chemistry Letters and Reviews

Andrew P. Dicks¹ 

关键词: solvent-free reactivity;    Twelve Principles;    organic synthesis;    microwave reactivity;    education;   

DOI  :  10.1080/17518250903164549

学科分类：化学（综合）

来源: Taylor & Francis

【 摘 要 】

This review highlights progress made since 2000 in the development of solvent-free organic reactions for student use. It is directed at university instructors to illustrate the broad scope of solventless reactivity possible in undergraduate laboratories. Eliminating a reaction medium directly addresses the Twelve Principles of Green Chemistry and is a focal point of contemporary industrial research. Experimental conditions are straightforward to implement and include reactant grinding, room temperature stirring, microwave irradiation, and conventional heating. A wide range of functional group transformations is easily achievable. Solvent-free reactions are often complete in a matter of minutes and routinely require simplistic work-up and purification protocols. Procedures are compiled from educational resources (primarily pedagogical journals and laboratory manuals) and corollary green experimental elements emphasized where possible.

【 授权许可】

Unknown