A fast and highly efficient one-pot synthesis of novel isoxazolyl pyrido[2,3-b][1,4]oxazin-2(3H)-ones via Smiles rearrangement using task-specific ionic liquid [HMIm]BF4 as green solvent

Green Chemistry Letters and Reviews

Modugu Nagi Reddy¹ 

关键词: Isoxazolyl pyrido[2;    3-b][1;    4]oxazin-2(3H)-ones;    Smiles rearrangement;    ionic liquid;    green chemistry;   

DOI  :  10.1080/17518253.2017.1285966

学科分类：化学（综合）

来源: Taylor & Francis

【 摘 要 】

A facile and convenient procedure for the synthesis of isoxazolyl pyrido[2,3-b][1,4]oxazin-2(3H)-ones via Smiles rearrangement from isoxazole amine, chloroacetyl chloride and 2-chloro-3-hydroxypyridine using [HMIm]BF4 as task-specific ionic liquid has been described. The protocol proves to be efficient and environmentally benign in terms of high yields, eco-friendly solvent, ease of recovery, and reusability of reaction medium.

【 授权许可】

Unknown