Development of anticancer agents targeting the Wnt/β-catenin signaling

American Journal of Cancer Research

Xiangqian Zhang¹ 

关键词: Wnt/β;    -catenin signaling;    β;    -catenin;    cancer;    small molecules;    biologic agents;    therapeutic;    safety and clinic;   

DOI  :  

学科分类：肿瘤学

来源: e-Century Publishing Corporation

【 摘 要 】

Wnt/β-catenin signaling plays indispensable roles in both embryonic development and adult homeostasis. Abnormal regulation of this pathway is implicated in many types of cancer. Consequently, substantial efforts have made to develop therapeutic agents as anticancer drugs by specifically targeting the Wnt/β-catenin pathway. Here we systematically review the potential therapeutic agents that have been developed to date for inhibition of the Wnt/β-catenin cascade as well as current status of clinical trials of some of these agents.

【 授权许可】

CC BY-NC