Experimental evaluation of anti-inflammatory, antinociceptive and antipyretic activities of clove oil in mice

Libyan journal of medicine

Yousef A. Taher¹ 

关键词: Eugenia caryophyllata;    clove oil;    eugenol;    antinociceptive;    anti-inflammatory;    antipyretic;    mice;   

DOI  :  10.3402/ljm.v10.28685

学科分类：医学（综合）

来源: Co-Action Publishing

【 摘 要 】

BackgroundClove oil of Eugenia caryophyllata (Myrtaceae) is a light yellowish fluid obtained from dried flower buds. Clove oil is used traditionally to relieve toothache.AimThe aim of the present work was to study the anti-inflammatory, antinociceptive and antipyretic potential of clove oil in mice.MethodsAnalgesic activity was examined using acetic-acid-induced abdominal constrictions and the hot plate test. Carrageenan-induced paw edema and brewer's-yeast-induced pyrexia were used to investigate the anti-inflammatory activity and the antipyretic effects, respectively. The oil was administered intraperitoneally (i.p.) at a dose of 33 mg/kg body weight and the effects were compared with reference drugs.ResultsIn the antinociceptive test, mice treated with clove oil exhibited significantly decreased acetic-acid-induced writhing movements by a maximum of 87.7% (p<0.01) compared with a decrease of 77.7% (p<0.01) in response to aspirin injection (100 mg/kg, intraperitoneal, i.p.). Similarly, in the hot plate ...

【 授权许可】

CC BY