International Journal of Clinical and Experimental Pathology | |
Thyroid cancer in systemic lupus erythematosus: a meta analysis | |
Min Zhang1  | |
关键词: Meta-analysis; systemic lupus erythematosus; standardized incidence ratio; thyroid cancer; | |
DOI : | |
学科分类:生理学与病理学 | |
来源: e-Century Publishing Corporation | |
【 摘 要 】
Objective: Considering inconclusive and heterogenous results, the aim of this study was to investigate the risk of thyroid cancer in systemic lupus erythematosus (SLE) by a quantitatively systematic review with meta-analysis. Methods: Electronic database of PubMed was searched for studies characterizing the associated risk of thyroid cancer in patients with SLE. The meta-analysis procedure was used to combine standardized incidence rates (SIRs) with 95% confidence intervals (CIs) to evaluate the association. Results: Seven cohort studies fulfilled the inclusion criteria and were subjected to the final analysis in the meta-analysis. Homogeneity was confirmed across the included studies. The pooled SIR based on a fixed-effect model was 2.22, with a 95% CI of 2.11-2.34. Sensitivity analyses suggested that the summary statistics obtained should approximate the actual average. Conclusion: Findings from this meta-analysis revealed the positive association between thyroid cancer and SLE risk. Individuals with SLE have a heightened risk of developing thyroid cancer.
【 授权许可】
CC BY-NC
【 预 览 】
Files | Size | Format | View |
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RO201904036398919ZK.pdf | 213KB | download |