A combination of plasma DAO and citrulline levels as a potential marker for acute mesenteric ischemia

Libyan journal of medicine

Rıdvan Çakmaz¹ 

关键词: animal model;    experimental;    intestines;    diamine oxidase;    citrulline;   

DOI  :  10.3402/ljm.v8i0.20596

学科分类：医学（综合）

来源: Co-Action Publishing

【 摘 要 】

IntroductionThere is no valid and reliable diagnostic test for early diagnosis of acute mesenteric ischemia (AMI). The aim of this study was to measure the plasma levels of diamine oxidase (DAO) and citrulline in AMI to gain insight into its early diagnosis.Material and methodsA total of 21 Wistar albino rats were divided into three groups, that is, control group, short-term ischemia group, and prolonged ischemia group. The superior mesenteric artery was occluded for 15 min in the short-term ischemia group and for 12 h in the prolonged ischemia group. Twelve hours later, the experiment was terminated and plasma DAO and citrulline levels were measured. Intestinal tissue was evaluated for the histopathological changes.ResultsCompared to the control group, the short-term and prolonged ischemia groups showed significant increases in the plasma levels of DAO, whereas the plasma citrulline levels decreased significantly. Prolonged ischemia caused a larger increase in the plasma DAO levels and a larger decrease ...

【 授权许可】

CC BY