Blood Glutathione Peroxidase Activity in Patients with Osteoarthritis Treated with Oxicams

Current Health Sciences Journal

DENISA-CONSTANTINA AMZOIUreplacement¹ 

关键词: oxicam;    NSAIDs;    glutathione peroxidase;    oxidative stress;    osteoarthritis;   

DOI  :  10.12865/CHSJ.42.01.04

学科分类：医学（综合）

来源: Universitatea de Medicina si Farmacie din Craiova / University of Medicine and Pharmacy

【 摘 要 】

Purpose. The main objective of this study was the comparison of the influence for three non-steroidal anti-inflammatory drugs (NSAIDs) belonging to the oxicam class, namely piroxicam and tenoxicam, as non-selective inhibitors of cyclooxygenase (COX), and meloxicam, a selective COX-2 inhibitor, on glutathione peroxidase (GPx) activity in patients with osteoarthritis of the knee. Material/Methods. Thirty adult subjects clinically and radiographically diagnosed with knee osteoarthritis, who were not previously subjected to any treatment, were enrolled. They were divided in three groups, each with ten subjects. The serum levels of GPx were assessed at baseline and after twenty days of treatment. The first group received piroxicam at a dose of 20 mg orally daily, the second group was treated with tenoxicam at a dose of 20 mg orally daily, and in the third group meloxicam was administrated in a dose of 15 mg orally daily. Results. After the treatment, it was observed an increase of the GPx a.

【 授权许可】

Unknown