СТЕРЕОТАКСИЧЕСКАЯ РАДИОХИРУРГИЯ «ГАММА-НОЖ» КАК АЛЬТЕРНАТИВА ЭНУКЛЕАЦИИ У ПАЦИЕНТОВ С УВЕАЛЬНОЙ МЕЛАНОМОЙ (ПЕРВЫЕ РЕЗУЛЬТАТЫ)

Oftal mokhirurgiya

О. В. Голубева¹  И. М. Горшков¹  А. А. Яровой¹  С. Р. Ильялов²  В. В. Костюченко²  А. В. Голанов² 

[1] МНТК «Микрохирургия глаза» им. акад. С.Н. Федорова, Москва;НИИ нейрохирургии им. акад. Н.Н. Бурденко» РАМН, Москва

关键词: gamma-knife;    stereotactic radiosurgery;    uveal melanoma;    eye enucleation;    Гамма-нож;    стереотаксическая радиохирургия;    меланома хориоидеи;    энуклеация;   

DOI  :  10.25276/0235-4160-2014-2-74-80

学科分类：眼科学

来源: M H T K Mikrokhirurgiya Glaza

【 摘 要 】

Development of stereotactic radiosurgery in ophthalmology started in the 1980s. Positive results in the Gamma-knife application were achieved in treatment of large uveal melanomas as an alternative for enucleation. The experience of Gamma-knife application inRussiais minimal.Purpose. To present the earliest results of treatment of patients with large uveal melanomas using the Gamma-knife radiosurgery.Material and methods. The study includes 7 patients with uveal melanoma (Т2-3N0M0) treated from June 2012 to December2013. Inall cases stereotactic radiosurgery was an alternative of eye enucleation and in 6 cases was a primary treatment. Irradiation was conducted according to the traditional planning technique irradiation with a 35-40 Gy by 50% isodose with maximum in tumor of 70-80 Gy. Follow-up was 2-18 months and in out-patients conditions.Results. The eyes and vision were preserved in 6 cases out of 7. Mean tumor regression was 2.8mm within more than 1 year. The main complication was radiation retinopathy of various manifestation.Conclusions. Gamma-knife radiosurgery allows to preserve the eyes with large uveal melanoma. Degree of radiogenic complications is not fatal for the eye. Nevertheless, a further follow-up is required for the treated patients to study possibilities of the method.

【 授权许可】

CC BY