DMF mediated Henry reaction of isatins: an efficient synthesis of 3-hydroxy-2-oxindole

Green Chemistry Letters and Reviews

Harshadas M. Meshram¹ 

关键词: DMF mediated reaction;    Henry reaction;    Isatin;    Nitroalkane;    3-Hydroxy-2-oxindole;   

DOI  :  10.1080/17518253.2012.701337

学科分类：化学（综合）

来源: Taylor & Francis

【 摘 要 】

An efficient Henry reaction has been described for the synthesis of 3-hydroxy-3-(nitroalkyl)-2-oxindole by the reaction of isatins with nitroalkanes in N,N-dimethylformamide (DMF) under anhydrous condition. This method provides high yield of 3-hydroxy-2-oxindoles under mild reaction condition. Moreover, the procedure is environmentally benign in nature, efficient, and applicable to variety of isatins as well as nitroalkanes.

【 授权许可】

Unknown