The effect of GABAmimetics on the duration of immobility in the forced swim test in albino mice

Libyan journal of medicine

Najwa Ahmed El zahaf¹ 

关键词: GABAmimetics;    forced swim test;    diazepam;    vigabatrin;    zolpidem;    alprazolam;   

DOI  :  10.3402/ljm.v9.23480

学科分类：医学（综合）

来源: Co-Action Publishing

【 摘 要 】

ObjectivesStudies regarding the role of gamma aminobutyric acid (GABA) in depression are conflicting. Therefore, it was decided to examine the effect of different drugs that enhance the GABA system on the time of immobility induced by the forced swim test (FST).Materials and methodsAdult albino mice were divided into several groups of six animals. Each group received an intraperitoneal injection of either imipramine (10, 20, or 30 mg/kg), diazepam (0.5, 1, or 2 mg/kg), vigabatrin (100, 200, or 300 mg/kg), zolpidem (2.5, 5, or 10 mg/kg), or alprazolam (1, 2.5, or 5 mg/kg). Control groups received the appropriate vehicle. One hour after injection, the duration of immobility was measured for 5 min in the FST. The percentage change in the duration of immobility from the control was calculated for each group. The statistical test of the difference between the treated and the control groups was calculated using unpaired Student's t-test.ResultsImipramine produced a significant dose-dependent decrease in the dur...

【 授权许可】

CC BY